The association between marijuana and schizophrenia is historically fraught. In the 1960s and 1970s, scientists thought that smoking weed could trigger psychosis in just about anyone. The resulting studies suggest that the neurobiology underlying schizophrenia might also put people affected by the disorder at increased risk for smoking pot. Now, a new study, published today in Molecular Psychiatry, lends further support to the idea that schizophrenia plays a role in an individuals likelihood of smoking weed, by showing that the genetic variants predicting schizophrenia can also be used to predict a persons tendency to smoke pot, regardless of their mental health history.