The Simpsons has become a cultural monolith since it first aired 25 seasons ago (and counting). The live show will be hosted by Hank Azaria, the voice of several Springfield inhabitants, with appearances from Nancy Cartwright (Bart) and Yeardley Smith (Lisa). Matt Groening, the creator of The Simpsons, will also perform, giving the audience anecdotes about working on the series as guests like Weird Al drift on and off stage.